Building computational research capacities is a crucial aspect of addressing the challenges of dementia in Africa. Computational research, including bioinformatics, data science, and artificial intelligence, play a significant role in understanding the underlying mechanisms of neurodegenerative disorders, identifying potential biomarkers, developing predictive models, and exploring novel therapeutic interventions. In the context of AD/ADRD, computational researchers can help analyze large datasets, including genomic, proteomic, and neuroimaging data, to uncover patterns, associations, and potential targets for intervention. By leveraging computational techniques such as machine learning and network analysis, researchers can gain insights into the complex interactions underlying dementia pathophysiology, thus facilitating the discovery of new diagnostic tools and therapeutic approaches for heterogeneous populations such as those of Africa.